Ras regulation by reactive oxygen and nitrogen species.

  title={Ras regulation by reactive oxygen and nitrogen species.},
  author={Jongyun Heo and Sharon L. Campbell},
  volume={45 7},
Ras GTPases cycle between inactive GDP-bound and active GTP-bound states to modulate a diverse array of processes involved in cellular growth control. We have previously shown that both NO/O(2) (via nitrogen dioxide, (*)NO(2)) and superoxide radical anion (O(2)(*)(-)) promote Ras guanine nucleotide dissociation. We now show that hydrogen peroxide in the presence of transition metals (i.e., H(2)O(2)/transition metals) and peroxynitrite also trigger radical-based Ras guanine nucleotide… CONTINUE READING


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