Ras regulates assembly of mitogenic signalling complexes through the effector protein IMP

@article{Matheny2004RasRA,
  title={Ras regulates assembly of mitogenic signalling complexes through the effector protein IMP},
  author={Sharon A. Matheny and Chiyuan Chen and Robert L. Kortum and Gina L. Razidlo and Robert E. Lewis and Michael A. White},
  journal={Nature},
  year={2004},
  volume={427},
  pages={256-260}
}
The signal transduction cascade comprising Raf, mitogen-activated protein (MAP) kinase kinase (MEK) and MAP kinase is a Ras effector pathway that mediates diverse cellular responses to environmental cues and contributes to Ras-dependent oncogenic transformation. Here we report that the Ras effector protein Impedes Mitogenic signal Propagation (IMP) modulates sensitivity of the MAP kinase cascade to stimulus-dependent activation by limiting functional assembly of the core enzymatic components… 

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TLDR
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TLDR
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TLDR
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TLDR
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    The international journal of biochemistry & cell biology
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...

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