Ras pathway inhibition prevents neovascularization by repressing endothelial cell sprouting.

@article{Westenskow2013RasPI,
  title={Ras pathway inhibition prevents neovascularization by repressing endothelial cell sprouting.},
  author={Peter D. Westenskow and Toshihide Kurihara and Edith Aguilar and Elizabeth L Scheppke and Stacey K. Moreno and Carli M. Wittgrove and Valentina Marchetti and Iacovos P Michael and Sudarshan Anand and Andras D Nagy and David A. Cheresh and Martin Friedlander},
  journal={The Journal of clinical investigation},
  year={2013},
  volume={123 11},
  pages={4900-8}
}
Vascular networks develop from a growing vascular front that responds to VEGF and other guidance cues. Angiogenesis is required for normal tissue function, but, under conditions of stress, inappropriate vascularization can lead to disease. Therefore, inhibition of angiogenic sprouting may prevent neovascularization in patients with blinding neovascular eye diseases, including macular degeneration. VEGF antagonists have therapeutic benefits but also can elicit off-target effects. Here, we found… CONTINUE READING