Ras pathway activates epithelial Na+ channel and decreases its surface expression in Xenopus oocytes.

@article{Mastroberardino1998RasPA,
  title={Ras pathway activates epithelial Na+ channel and decreases its surface expression in Xenopus oocytes.},
  author={Luca Mastroberardino and Benjamin Spindler and Ian C. Forster and Johannes Loffing and R. Assandri and Anne May and François Verrey},
  journal={Molecular biology of the cell},
  year={1998},
  volume={9 12},
  pages={
          3417-27
        }
}
The small G protein K-Ras2A is rapidly induced by aldosterone in A6 epithelia. In these Xenopus sodium reabsorbing cells, aldosterone rapidly activates preexisting epithelial Na+ channels (XENaC) via a transcriptionally mediated mechanism. In the Xenopus oocytes expression system, we tested whether the K-Ras2A pathway impacts on XENaC activity by expressing XENaC alone or together with XK-Ras2A rendered constitutively active (XK-Ras2AG12V). As a second control, XENaC-expressing oocytes were… 

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