Ras nanoclusters: Versatile lipid-based signaling platforms.

  title={Ras nanoclusters: Versatile lipid-based signaling platforms.},
  author={Yong Zhou and John F Hancock},
  journal={Biochimica et biophysica acta},
  volume={1853 4},
Ras proteins assemble into transient nanoclusters on the plasma membrane. Nanoclusters are the sites of Ras effector recruitment and activation and are therefore essential for signal transmission. The dynamics of nanocluster formation and disassembly result in interesting emergent properties including high-fidelity signal transmission. More recently the lipid structure of Ras nanoclusters has been reported and shown to contribute to isoform-specific Ras signaling. In addition specific lipids… CONTINUE READING
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