Ras-mediated phosphorylation of a conserved threonine residue enhances the transactivation activities of c-Ets1 and c-Ets2.

@article{Yang1996RasmediatedPO,
  title={Ras-mediated phosphorylation of a conserved threonine residue enhances the transactivation activities of c-Ets1 and c-Ets2.},
  author={Boh Suk Yang and C. A. Hauser and Gerald Henkel and Martin Colman and Charles Van Beveren and Katryn J. Stacey and David A. Hume and Richard A Maki and Michael C. Ostrowski},
  journal={Molecular and cellular biology},
  year={1996},
  volume={16 2},
  pages={538-47}
}
The Ras oncogene products regulate the expression of genes in transformed cells, and members of the Ets family of transcription factors have been implicated in this process. To determine which Ets factors are the targets of Ras signaling pathways, the abilities of several Ets factors to activate Ras-responsive enhancer (RRE) reporters in the presence of oncogenic Ras were examined. In transient transfection assay, reporters containing RREs composed of Ets-AP-1 binding sites could be activated… CONTINUE READING
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