Ras is essential for nerve growth factor- and phorbol ester-induced tyrosine phosphorylation of MAP kinases.

@article{Thomas1992RasIE,
  title={Ras is essential for nerve growth factor- and phorbol ester-induced tyrosine phosphorylation of MAP kinases.},
  author={Sheila M. Thomas and Monica Demarco and G V D'arcangelo and Simon Halegoua and Joan S. Brugge},
  journal={Cell},
  year={1992},
  volume={68 6},
  pages={1031-40}
}
Treatment of PC12 cells with nerve growth factor (NGF) induces a rapid increase in tyrosine phosphorylation of multiple cellular proteins. Expression of a dominant inhibitory Ras mutant specifically blocked NGF- and TPA-induced tyrosine phosphorylation of two proteins of approximately 42 and 44 kd. Conversely, expression of an oncogenic variant of Ras induced tyrosine phosphorylation of the same 42 and 44 kd proteins. The 44 kd protein was immunoprecipitated with an antibody directed against… CONTINUE READING

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Autophosphorylation in vitroof recombinant 42 kDa mitogen-activated protein kinase on tyrosine

  • J. Wu, A. J. Rossomando, +4 authors T. W. Sturgill
  • Proc. Natl. Acad. Sci. USA 88, 9506-9512.
  • 1991
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