Ras induces experimental lung metastasis through up-regulation of RbAp46 to suppress RECK promoter activity

@inproceedings{Yeh2015RasIE,
  title={Ras induces experimental lung metastasis through up-regulation of RbAp46 to suppress RECK promoter activity},
  author={H Yeh and Yu-Fen Tseng and Yu-Chiao Hsu and Sheng-Hui Lan and Shan-Ying Wu and Giri Raghavaraju and Da-En Cheng and Ying-Ray Lee and T L Chang and N. H. Chow and W R Hung and Hsiao-Sheng Liu},
  booktitle={BMC Cancer},
  year={2015}
}
Mutant Ras plays multiple functions in tumorigenesis including tumor formation and metastasis. Reversion-inducing cysteine-rich protein with Kazal motifs (RECK), a metastasis inhibitor gene, suppresses matrix metalloproteinase (MMP) activity in the metastatic cascade. Clarifying the relationship between Ras and RECK and understanding the underlying… CONTINUE READING