Ras induces anchorage-independent growth by subverting multiple adhesion-regulated cell cycle events.

@article{Kang1996RasIA,
  title={Ras induces anchorage-independent growth by subverting multiple adhesion-regulated cell cycle events.},
  author={J S Kang and Robert S Krauss},
  journal={Molecular and cellular biology},
  year={1996},
  volume={16 7},
  pages={3370-80}
}
Anchorage-independent growth is a hallmark of transformed cells, but little is known of the molecular mechanisms that underlie this phenomenon. We describe here studies of cell cycle control of anchorage-independent growth induced by the ras oncogene, with the use of a somatic cell mutant fibroblast line (ER-1-2) that is specifically defective in oncogene-mediated, anchorage-independent growth. Control, nontransformed PKC3-F4 cells and ER-1-2 cells cannot proliferate in semisolid medium. Three… CONTINUE READING