Ras-induced reactive oxygen species promote growth factor-independent proliferation in human CD34+ hematopoietic progenitor cells.

@article{Hole2010RasinducedRO,
  title={Ras-induced reactive oxygen species promote growth factor-independent proliferation in human CD34+ hematopoietic progenitor cells.},
  author={Paul Spencer Hole and Lorna Pearn and Amanda Jayne Tonks and Philip E. James and Alan K. Burnett and Richard Lawrence Darley and Alex Tonks},
  journal={Blood},
  year={2010},
  volume={115 6},
  pages={1238-46}
}
Excessive production of reactive oxygen species (ROS) is a feature of human malignancy and is often triggered by activation of oncogenes such as activated Ras. ROS act as second messengers and can influence a variety of cellular process including growth factor responses and cell survival. We have examined the contribution of ROS production to the effects of N-Ras(G12D) and H-Ras(G12V) on normal human CD34(+) progenitor cells. Activated Ras strongly up-regulated the production of both superoxide… CONTINUE READING

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Genomic instability ROS AUGMENTS PROLIFERATION PROMOTED BY Ras 1245 BLOOD

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