Ras-independent activation of Rel-family transcription factors by UVB and TPA in cultured keratinocytes.

@article{Tobin1996RasindependentAO,
  title={Ras-independent activation of Rel-family transcription factors by UVB and TPA in cultured keratinocytes.},
  author={Derek Tobin and Mikael Nilsson and Rune Toftg{\aa}rd},
  journal={Oncogene},
  year={1996},
  volume={12 4},
  pages={785-93}
}
UV irradiation of mammalian cells results in the activation of transcription factors which mediate induction of early response genes designed to repair and minimise the damage sustained by the cell. Evidence from studies in HeLa cells suggest that UVC regulates NF-kappa B activity via tyrosine kinases and activation of Ras and Raf kinase. In this study we have used a previously characterized TPA-responsive element (VLTRE) that binds Rel/NF-kappa B proteins and a Ras-responsive element (B10 RRE… CONTINUE READING

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