Ras-independent activation of Ral by a Ca2+-dependent pathway


The RalA and RalB proteins comprise a distinct family of small GTPases [1]. Ral-specific guanine-nucleotide exchange factors such as RalGDS, Rlf and RGL interact with activated Ras and cooperate with Ras in the transformation of murine fibroblasts [2-5]. Thus, the interaction of RalGDS with Ras and the subsequent activation of Ral are thought to constitute… (More)
DOI: 10.1016/S0960-9822(98)70327-6


3 Figures and Tables

Cite this paper

@article{Hofer1998RasindependentAO, title={Ras-independent activation of Ral by a Ca2+-dependent pathway}, author={Franz Hofer and Rebecca Berdeaux and G. Steven Martin}, journal={Current Biology}, year={1998}, volume={8}, pages={839-844} }