Ras-dependent activation of MAP kinase pathway mediated by G-protein βγ subunits

@article{Crespo1994RasdependentAO,
  title={Ras-dependent activation of MAP kinase pathway mediated by G-protein βγ subunits},
  author={Piero Crespo and Ningzhi Xu and William F. Simonds and J. Silvio Gutkind},
  journal={Nature},
  year={1994},
  volume={369},
  pages={418-420}
}
MITOGEN-ACTIVATED protein kinases, MAP kinases or ERKs (extracellular signal-regulated kinases) are rapidly stimulated by growth-promoting factors acting on a variety of cell-surface receptors1,2. In turn, ERKs phosphorylate and regulate key intra-cellular enzymes and transcription factors involved in the control of cellular proliferation3,4. The tyrosine-kinase class of growth-factor receptors transmits signals to ERKs in a multistep process that involves Ras and a limited number of defined… CONTINUE READING

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