Ras binding opens c-Raf to expose the docking site for mitogen-activated protein kinase kinase.

@article{Terai2005RasBO,
  title={Ras binding opens c-Raf to expose the docking site for mitogen-activated protein kinase kinase.},
  author={Kenta Terai and Michiyuki Matsuda},
  journal={EMBO reports},
  year={2005},
  volume={6 3},
  pages={251-5}
}
A key signalling molecule, c-Raf, is situated downstream from Ras and upstream from the mitogen-activated protein kinase kinase (MEK). We studied the mechanism underlying the signal transduction from Ras to MEK by using probes based on the principle of fluorescence resonance energy transfer. In agreement with previous models, it was found that c-Raf adopted two conformations: open active and closed inactive. Ras binding induced the c-Raf transition from closed to open conformation, which… CONTINUE READING

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We studied the mechanism underlying the signal transduction from Ras to MEK by using probes based on the principle of fluorescence resonance energy transfer .
We studied the mechanism underlying the signal transduction from Ras to MEK by using probes based on the principle of fluorescence resonance energy transfer .
A key signalling molecule , c - Raf , is situated downstream from Ras and upstream from the mitogen - activated protein kinase kinase ( MEK ) .
A key signalling molecule , c - Raf , is situated downstream from Ras and upstream from the mitogen - activated protein kinase kinase ( MEK ) .
A key signalling molecule , c - Raf , is situated downstream from Ras and upstream from the mitogen - activated protein kinase kinase ( MEK ) .
A key signalling molecule , c - Raf , is situated downstream from Ras and upstream from the mitogen - activated protein kinase kinase ( MEK ) .
A key signalling molecule , c - Raf , is situated downstream from Ras and upstream from the mitogen - activated protein kinase kinase ( MEK ) .
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