Ras and Rap Control AMPA Receptor Trafficking during Synaptic Plasticity

  title={Ras and Rap Control AMPA Receptor Trafficking during Synaptic Plasticity},
  author={J.Julius Zhu and Yi Qin and Mingming Zhao and Linda van Aelst and Roberto Malinow},
Recent studies show that AMPA receptor (-R) trafficking is important in synaptic plasticity. However, the signaling controlling this trafficking is poorly understood. Small GTPases have diverse neuronal functions and their perturbation is responsible for several mental disorders. Here, we examine the small GTPases Ras and Rap in the postsynaptic signaling underlying synaptic plasticity. We show that Ras relays the NMDA-R and CaMKII signaling that drives synaptic delivery of AMPA-Rs during long… CONTINUE READING
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The organization complex: structural basis for GTPase activation and its loss in onco

  • M. Kohler, H. C. Kornau, P. H. Seeburg
  • 1994
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4 Excerpts

Rap 1 signalling : these drugs were included during recordings . Patch recording piadhering to new models

  • J. L. Bos, J. de Rooij, K. A. Reedquist
  • Nat . Rev . Mol . Cell . Biol .
  • 2001
Highly Influential
3 Excerpts

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