Ras and Rap Control AMPA Receptor Trafficking during Synaptic Plasticity

@article{Zhu2002RasAR,
  title={Ras and Rap Control AMPA Receptor Trafficking during Synaptic Plasticity},
  author={J.Julius Zhu and Yi Qin and Mingming Zhao and Linda van Aelst and Roberto Malinow},
  journal={Cell},
  year={2002},
  volume={110},
  pages={443-455}
}
Recent studies show that AMPA receptor (-R) trafficking is important in synaptic plasticity. However, the signaling controlling this trafficking is poorly understood. Small GTPases have diverse neuronal functions and their perturbation is responsible for several mental disorders. Here, we examine the small GTPases Ras and Rap in the postsynaptic signaling underlying synaptic plasticity. We show that Ras relays the NMDA-R and CaMKII signaling that drives synaptic delivery of AMPA-Rs during long… CONTINUE READING
Highly Influential
This paper has highly influenced 58 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
308 Extracted Citations
75 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 308 extracted citations

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 75 references

The organization complex: structural basis for GTPase activation and its loss in onco

  • M. Kohler, H. C. Kornau, P. H. Seeburg
  • 1994
Highly Influential
4 Excerpts

Rap 1 signalling : these drugs were included during recordings . Patch recording piadhering to new models

  • J. L. Bos, J. de Rooij, K. A. Reedquist
  • Nat . Rev . Mol . Cell . Biol .
  • 2001
Highly Influential
3 Excerpts

Similar Papers

Loading similar papers…