Ras activity in acinar cells links chronic pancreatitis and pancreatic cancer.

@article{Logsdon2009RasAI,
  title={Ras activity in acinar cells links chronic pancreatitis and pancreatic cancer.},
  author={Craig D. Logsdon and Baoan Ji},
  journal={Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association},
  year={2009},
  volume={7 11 Suppl},
  pages={S40-3}
}
The relationship between chronic pancreatitis (CP) and pancreatic ductal adenocarcinoma (PDAC) is unclear. CP is a risk factor for PDAC, CP is found within the vicinity of PDAC, and both share many similar genetic alterations. However, it has been long thought that PDAC arises only from duct cells. However, we have recently found that excessive activity within the Ras signaling pathway can lead to acinar cell death or metaplasia and is associated with the development of fibrosis resembling CP… CONTINUE READING

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