Ras activation in response to lysophosphatidic acid requires a permissive input from the epidermal growth factor receptor.

@article{Rubio2003RasAI,
  title={Ras activation in response to lysophosphatidic acid requires a permissive input from the epidermal growth factor receptor.},
  author={Ignacio Rubio and Knut Rennert and Ute Wittig and Reinhard Wetzker},
  journal={The Biochemical journal},
  year={2003},
  volume={376 Pt 3},
  pages={571-6}
}
The topology of the signalling pathway linking the G-protein-coupled receptor agonist lysophosphatidic acid (LPA) to extracellular-signal-regulated kinase activation remains undeciphered. In the present study, we report that analysis of LPA signals at the level of Ras-GTP formation and Ras nucleotide exchange discriminates true mediatory signals from… CONTINUE READING