Ras activation in astrocytomas and neurofibromas.

  title={Ras activation in astrocytomas and neurofibromas.},
  author={A Guha},
  journal={The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques},
  volume={25 4},
  • A Guha
  • Published 1998 in
    The Canadian journal of neurological sciences. Le…
Oncogenic mutations resulting in activated Ras Guanosine Triphosphate (GTP) are prevalent in 30% of all human cancers, but not primary nervous system tumors. Several growth factors/receptors are implicated in the pathogenesis of malignant astrocytomas including epidermal growth factor (EGFR) and platelet derived growth factor (PDGF-R) receptors, plus the highly potent and specific angiogenic vascular endothelial growth factor (VEGF). A significant proportion of these tumors also express a… CONTINUE READING

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