Ras-Raf-Arf signaling critically depends on the Dmp1 transcription factor.

  title={Ras-Raf-Arf signaling critically depends on the Dmp1 transcription factor.},
  author={Ramesh Sreeramaneni and Asif A. Chaudhry and Martin McMahon and Charles J Sherr and Kazushi Inoue},
  journal={Molecular and cellular biology},
  volume={25 1},
Dmp1 prevents tumor formation by activating the Arf-p53 pathway. In cultured primary cells, the Dmp1 promoter was efficiently activated by oncogenic Ha-Ras(V12), but not by overexpressed c-Myc or E2F-1. Dmp1 promoter activation by Ras(V12) depended on Raf-MEK-ERK signaling. Induction of p19(Arf) and p21(Cip1) by oncogenic Raf was compromised in Dmp1-null cells, which were resistant to Raf-mediated premature senescence. A Ras(V12)-responsive element was mapped to the 5' leader sequence of the… CONTINUE READING

From This Paper

Topics from this paper.
64 Citations
0 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 64 extracted citations

Similar Papers

Loading similar papers…