Ras Promotes Transforming Growth Factor-β (TGF-β)-induced Epithelial-Mesenchymal Transition via a Leukotriene B4 Receptor-2-linked Cascade in Mammary Epithelial Cells*

@article{Kim2014RasPT,
  title={Ras Promotes Transforming Growth Factor-β (TGF-β)-induced Epithelial-Mesenchymal Transition via a Leukotriene B4 Receptor-2-linked Cascade in Mammary Epithelial Cells*},
  author={Ho Young Kim and Jung-A Choi and Jae-Hong Kim},
  journal={The Journal of Biological Chemistry},
  year={2014},
  volume={289},
  pages={22151 - 22160}
}
  • Ho Young Kim, Jung-A Choi, Jae-Hong Kim
  • Published in
    The Journal of Biological…
    2014
  • Biology, Medicine
  • Background: The mechanism by which oncogenic Ras contributes to epithelial-mesenchymal transition (EMT) is not clearly defined. Results: The “BLT2-ROS-NF-κB”-linked cascade lies downstream of Ras and promotes EMT. Conclusion: Activation of leukotriene B4 receptor-2 (BLT2)-linked pathway contributes to EMT in mammary epithelial cells. Significance: These findings suggest that BLT2 is a novel regulator of EMT in mammary epithelial cells. Inflammation and inflammatory mediators are inextricably… CONTINUE READING

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