Ras GTPase-activating protein binds to Akt and is required for its activation.

@article{Yue2004RasGP,
  title={Ras GTPase-activating protein binds to Akt and is required for its activation.},
  author={Yingzi Yue and Jaqueline Lypowy and Nadia Hedhli and M. L. Abdellatif},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 13},
  pages={12883-9}
}
RasGAP (Ras GTPase-activating protein) is a negative regulator as well as a downstream effector of Ras. To identify partners of RasGAP we used it as the bait in a yeast two-hybrid screen. This resulted in discovering its interaction with Akt. Overexpression of RasGAP or a mutant lacking the GTPase-activating domain (nGAP) enhanced phosphorylation and activity of Akt, which was dependent on the upstream integrin-linked kinase. Also, nGAP protected the cells against staurosporin-induced apoptosis… CONTINUE READING
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