Ras-GTPase activating protein (GAP): a putative effector for Ras.

  title={Ras-GTPase activating protein (GAP): a putative effector for Ras.},
  author={Bruno Tocqu{\'e} and Isabelle Delumeau and Fabienne Parker and Florence Maurier and M C Multon and F Schweighoffer},
  journal={Cellular signalling},
  volume={9 2},
One attractive candidate for a Ras effector protein, other than the Raf kinases, is Ras-GAP. Indeed, recent literature suggests that besides the Raf/MAP kinase cascade, additional pathways must be stimulated to elicit a full biological response to Ras. Ras binds the COOH terminal domain of Ras-GAP, while the NH2 terminal domain appears to be essential for triggering downstream signals. Since Ras-GAP itself has no obvious enzymatic function that might explain a role in processes associated with… CONTINUE READING

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