Ras GTPase-Like Protein MglA, a Controller of Bacterial Social-Motility in Myxobacteria, Has Evolved to Control Bacterial Predation by Bdellovibrio

@article{Milner2014RasGP,
  title={Ras GTPase-Like Protein MglA, a Controller of Bacterial Social-Motility in Myxobacteria, Has Evolved to Control Bacterial Predation by Bdellovibrio},
  author={David S. Milner and R. Till and I. Cadby and A. Lovering and Sarah M. Basford and Emma B. Saxon and S. Liddell and L. E. Williams and R. E. Sockett},
  journal={PLoS Genetics},
  year={2014},
  volume={10}
}
  • David S. Milner, R. Till, +6 authors R. E. Sockett
  • Published 2014
  • Biology, Medicine
  • PLoS Genetics
  • Bdellovibrio bacteriovorus invade Gram-negative bacteria in a predatory process requiring Type IV pili (T4P) at a single invasive pole, and also glide on surfaces to locate prey. Ras-like G-protein MglA, working with MglB and RomR in the deltaproteobacterium Myxococcus xanthus, regulates adventurous gliding and T4P-mediated social motility at both M. xanthus cell poles. Our bioinformatic analyses suggested that the GTPase activating protein (GAP)-encoding gene mglB was lost in Bdellovibrio, but… CONTINUE READING
    31 Citations

    Figures and Topics from this paper.

    The Lifestyle Switch Protein Bd0108 of Bdellovibrio bacteriovorus Is an Intrinsically Disordered Protein
    • 5
    • PDF
    The polar Ras-like GTPase MglA activates type IV pilus via SgmX to enable twitching motility in Myxococcus xanthus
    The small GTPase MglA together with the TPR domain protein SgmX stimulates type IV pili formation in M. xanthus
    • 1
    • PDF
    An Extended Cyclic Di-GMP Network in the Predatory Bacterium Bdellovibrio bacteriovorus.
    • 22
    • PDF
    Dynamics of Chromosome Replication and Its Relationship to Predatory Attack Lifestyles in Bdellovibrio bacteriovorus
    • 4
    • PDF

    References

    SHOWING 1-10 OF 51 REFERENCES
    Discrete Cyclic di-GMP-Dependent Control of Bacterial Predation versus Axenic Growth in Bdellovibrio bacteriovorus
    • 68
    • PDF
    Effects of site-directed mutagenesis of mglA on motility and swarming of Myxococcus xanthus
    • 10
    Bacterial motility complexes require the actin‐like protein, MreB and the Ras homologue, MglA
    • 118
    • PDF
    Structural analysis of the Ras-like G protein MglA and its cognate GAP MglB and implications for bacterial polarity
    • 76
    • PDF
    A Dynamic Response Regulator Protein Modulates G-Protein–Dependent Polarity in the Bacterium Myxococcus xanthus
    • 47
    • Highly Influential
    Transposon Insertions of magellan-4 That Impair Social Gliding Motility in Myxococcus xanthus
    • 50
    • PDF
    Characterizing the flagellar filament and the role of motility in bacterial prey-penetration by Bdellovibrio bacteriovorus
    • 111