Ras-GRF2 mediates long-term potentiation, survival, and response to an enriched environment of newborn neurons in the hippocampus.

@article{Darcy2014RasGRF2ML,
  title={Ras-GRF2 mediates long-term potentiation, survival, and response to an enriched environment of newborn neurons in the hippocampus.},
  author={Michael J Darcy and St{\'e}phanie Trouche and Shan-xue Jin and Larry A. Feig},
  journal={Hippocampus},
  year={2014},
  volume={24 11},
  pages={1317-29}
}
Hippocampal adult neurogenesis contributes to key functions of the dentate gyrus (DG), including contextual discrimination. This is due, at least in part, to the unique form of plasticity that new neurons display at a specific stage of their development when compared with the surrounding principal neurons. In addition, the contribution that newborn neurons make to dentate function can be enhanced by an increase in their numbers induced by a stimulating environment. However, signaling mechanisms… CONTINUE READING
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