Ras Activity in the Drosophila Prothoracic Gland Regulates Body Size and Developmental Rate via Ecdysone Release

@article{Caldwell2005RasAI,
  title={Ras Activity in the Drosophila Prothoracic Gland Regulates Body Size and Developmental Rate via Ecdysone Release},
  author={Philip E. Caldwell and Magdalena Walkiewicz and Michael Stern},
  journal={Current Biology},
  year={2005},
  volume={15},
  pages={1785-1795}
}
BACKGROUND In Drosophila, each of the three larval instars ends with a molt, triggered by release of steroid molting hormone ecdysone from the prothoracic gland (PG). Because all growth occurs during the larval stages, final body size depends on both the larval growth rate and the duration of each larval stage, which in turn might be regulated by the timing of ecdysone release. RESULTS Here, we show that the expression of activated Ras, PI3 kinase (PI3K), or Raf specifically in the PG reduces… CONTINUE READING
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