Ras-A Molecular Switch Involved in Tumor Formation.

Abstract

Ras, a GTP-hydrolyzing protein, is the product of a proto-oncogene found mutated in about 20-30 % of human tumors. It binds GDP/GTP with high affinity and in the presence of a GTPase-activating protein (GAP) has high GTP-hydrolyzing activity. The proto-oncogenic "normal" Ras functions as a regulated molecular switch cycling between a GDP-bound OFF and a GTP… (More)
DOI: 10.1002/1521-3773(20001201)39:23<4192::AID-ANIE4192>3.0.CO;2-Y

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