Rarity of TLR4 Asp299Gly and Thr399Ile Polymorphisms in the Korean Population

@inproceedings{Kim2008RarityOT,
  title={Rarity of TLR4 Asp299Gly and Thr399Ile Polymorphisms in the Korean Population},
  author={Yeun Sun Kim and You Jin Hwang and Sung Yong Kim and Sun Mee Yang and Ki young Lee and Ie Byung Park},
  booktitle={Yonsei medical journal},
  year={2008}
}
PURPOSE Activation of the innate immune system and chronic low-grade inflammation are thought to be involved in the pathogenesis of atherosclerosis and also thought to be associated with type 2 diabetes and its complications. As a receptor for bacterial lipopolysaccharide and heat-shock proteins, Toll-like receptor 4 (TLR4) is one of the central regulators of the immune response. Recent studies have reported an association between TLR4 polymorphisms and diabetes and its complications in… CONTINUE READING