Rare-variant extensions of the transmission disequilibrium test: application to autism exome sequence data.


Many population-based rare-variant (RV) association tests, which aggregate variants across a region, have been developed to analyze sequence data. A drawback of analyzing population-based data is that it is difficult to adequately control for population substructure and admixture, and spurious associations can occur. For RVs, this problem can be substantial… (More)
DOI: 10.1016/j.ajhg.2013.11.021


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