Rare tumors of the colon and rectum: a national review

  title={Rare tumors of the colon and rectum: a national review},
  author={Hakjung Kang and Jessica B O'connell and Michael J. Leonardi and Melinda A. Maggard and Marcia L. McGory and Clifford Y. Ko},
  journal={International Journal of Colorectal Disease},
BackgroundMost literature available on rare colorectal cancer (CRC) is from case series reports. This population-based evaluation is the first comprehensive look at four rare histologic types of CRC, allowing comparisons with the more common adenocarcinoma for clinical and pathological features and survival rates.Materials and ethodsAll patients diagnosed with carcinoid (n=2,565), malignant lymphoma (n=955), non-carcinoid neuroendocrine (n=455), squamous cell (n=437), and adenocarcinoma (n=164… 
Survival of Patients With Neuroendocrine Carcinoma of the Colon and Rectum: A Population-Based Analysis
Relatively poor survival in early stage neuroendocrine carcinoma warrants studies of adjuvant systemic therapy, and the differences in outcomes between small-cell and non–small-cell neuro endocrine carcinomas indicate a need for histology-specific management.
Colonic carcinoid tumors: a clinicopathologic study of 23 patients from a single institution.
Based on the relatively poor survival rates reported, it is recommended that, in addition to standard surgical resection, vigorous surveillance for metastatic disease must be performed, particularly during the first 2 years after surgery, because tumor recurrences after 5 years are not uncommon.
Colorectal Nonadenocarcinoma in South Korea
  • J. Huh
  • Medicine
    Annals of coloproctology
  • 2020
This analysis was performed to update the incidences of rare histological types of colorectal cancers in South Korea and found that surgical resection remains the gold standard management for GISTs, and imatinib is currently used in the neoadjuvant, adjuvant, and metastatic disease setting.
Prevalence of Neuroendocrine Tumors in the Gastrointestinal and Hepatobiliary Systems
There was a predominance of gastroduodenal and rectal carcinoid tumors, probably because the series analyzed was essentially endoscopic, and less cases of metastases or carcinoid syndrome were recorded and survival was greater, perhaps due to earlier diagnosis and treatment.
Sidedness determines clinical characteristics and survival outcomes in medullary adenocarcinoma of the colon
The reported incidence of MAC is increasing, in contrast to the declining incidence of AC, and clinical and molecular features are distinct from AC and likely account for outcome differences.
Basic characteristics and therapy regimens for colorectal squamous cell carcinoma
The results show that the colorectal SCC was commonly seen in females, and tends to have higher pT category and TNM stage, and its 5-year survival rate was much lower than adenocarcinoma or mucinous adenOCarcinomas and mucinousAdenoccarinoma and much higher than signet ring cell carcinoma.
Analysis of 72 patients with colorectal high-grade neuroendocrine neoplasms from three Chinese hospitals
Colorectal HGNENs are rare and aggressive malignancies with poor clinical outcomes, however, patients with younger age, good morphological differentiation, and without metastatic disease can have a relatively favorable prognosis.
Surgical treatment of extra-appendiceal colorectal neuroendocrine tumors.
Lower-grade neuro endocrine tumors seem to exhibit comparable potential for dissemination as neuroendocrine carcinomas, but prognostic implications of metastases are distinct.
Neuroendocrine neoplasms of rectum: A management update.


Colorectal cancers of rare histologic types compared with adenocarcinomas
Colorectal cancers of histologic varieties other than adenocarcinoma have distinctive epidemiologic and clinical traits and survival was better with colonic and rectal carcinoids and Rectal transitional cell-like cancers than with adenOCarcinomas.
Updated Population-Based Review of Carcinoid Tumors
Using national, population-based cancer registry data, this study demonstrates that incidence rates for carcinoid tumors have changed, the most common gastrointestinal site is not the appendix, but the small intestine, followed in frequency by the rectum, and survival rates differ between individual anatomic sites.
Adenosquamous and squamous carcinoma of the colon and upper rectum
Although a poor prognosis can be expected for node-positive disease, patients with negative nodes do generally the same as patients with adenocarcinoma histology, and further studies should define the role of postoperative therapies for these lesions.
Carcinoid Tumors of the Gastrointestinal Tract: A 44‐Year Experience
Patients treated for gastrointestinal carcinoid tumors between 1942 and 1986 had localized disease, primarily in the rectum and appendix, and the three most common sites were jejunum-ileum, rectum, and appendix.
Adenosquamous carcinoma of the colon, rectum, and anus
It is found that patients with colorectal and anal adenosquamous carcinomas staged B2 through D have significantly poorer survival than patients with comparably staged adenocarcinomas, supporting the previous reports of a poor prognosis associated with adenosqous carcinomas.
Lymphoma of the colon and rectum.
This review concentrates on the major series reported since 1960 in which sufficient information regarding factors has been given to allow conclusions to be drawn about colorectal lymphoma.
[Primary gastrointestinal non-Hodgkin's lymphomas].
The majority of investigators reported that gastric lymphoma was associated with better prognosis than intestinal lymphoma, one possible explanation being that Gastric lymphomas was more likely to be diagnosed at an earlier stage.
Primary malignant lymphoma of the colon and rectum. A histopathological and immunohistochemical analysis of 45 cases with clinicopathological correlations
The view that surgery should be the primary treatment for localized lymphoma of the gastrointestinal tract with radiotherapy and/or chemotherapy for advanced cases and for malignant lymphomatous polyposis is supported.
Prognosis and survival in patients with gastrointestinal tract carcinoid tumors.
Gastrointestinal tract carcinoid tumors have a nonspecific clinical presentation, except in the case of the carcinoid syndrome, and age, tumor size, depth, and location were significant predictors of metastases.