Rare sugar D-allose enhances anti-tumor effect of 5-fluorouracil on the human hepatocellular carcinoma cell line HuH-7.

@article{Yamaguchi2008RareSD,
  title={Rare sugar D-allose enhances anti-tumor effect of 5-fluorouracil on the human hepatocellular carcinoma cell line HuH-7.},
  author={Fuminori Yamaguchi and Kazuyo Kamitori and Keiko Sanada and Mariko Horii and Youyi Dong and L H Sui and Masaaki Tokuda},
  journal={Journal of bioscience and bioengineering},
  year={2008},
  volume={106 3},
  pages={248-52}
}
d-Allose is a novel anti-tumor monosaccharide that causes cell growth inhibition, specifically of the cancer cells, by inducing the tumor suppressor gene thioredoxin interacting protein (TXNIP). The commonly used anti-tumor drug, 5-fluorouracil (5-FU), blocks the cell cycle by inhibiting thymidylate synthase, and is also known to induce TXNIP gene expression. In this study, we examined the synergistic effect of d-allose and 5-FU and the role of TXNIP on cancer cell growth. The treatment of HuH… CONTINUE READING

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