Rare missense variants in ATP1A2 in families with clustering of common forms of migraine.

@article{Todt2005RareMV,
  title={Rare missense variants in ATP1A2 in families with clustering of common forms of migraine.},
  author={Unda Todt and Martin Dichgans and Karin Jurkat-Rott and Axel Heinze and Giovanni Zifarelli and Jan B. Koenderink and Ingrid Goebel and Vera Zumbroich and Anne Stiller and Alfredo Ramirez and Thomas Friedrich and Hartmut Goebel and Christian Kubisch},
  journal={Human mutation},
  year={2005},
  volume={26 4},
  pages={315-21}
}
Migraine is a recurrent neurovascular disease. Its two most common forms-migraine without aura (MO) and migraine with aura (MA)-both show familial clustering and a complex pattern of inheritance. Familial hemiplegic migraine (FHM) is a rare monogenic subform caused by mutations in the calcium channel gene CACNA1A or the Na(+)/K(+)-ATPase gene ATP1A2. An involvement of FHM genes in the pathogenesis of common forms of migraine is not proven. We therefore systematically screened ATP1A2 in families… CONTINUE READING
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Migraine

  • Silberstein SD.
  • Lancet 363:381–391.
  • 2004

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