Rare intronic variants of TCF7L2 arising by selective sweeps in an indigenous population from Mexico

Abstract

Genetic variations of the TCF7L2 gene are associated with the development of Type 2 diabetes (T2D). The associated mutations have demonstrated an adaptive role in some human populations, but no studies have determined the impact of evolutionary forces on genetic diversity in indigenous populations from Mexico. Here, we sequenced and analyzed the variation… (More)
DOI: 10.1186/s12863-016-0372-7

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