Rare expression of T-cell markers in classical Hodgkin's lymphoma

  title={Rare expression of T-cell markers in classical Hodgkin's lymphoma},
  author={Alexandar Tzankov and Caroline Bourgau and Alexandra Kaiser and Annette Zimpfer and Robert Maurer and Stefano Aldo Pileri and Philip Th Went and Stephan Dirnhofer},
  journal={Modern Pathology},
Hodgkin's and Reed–Sternberg cells of classical Hodgkin's lymphoma are primarily of B-cell origin, although there are instances of T-cell antigen expression suggesting T-cell origin. We comprehensively analyzed expression of various T-cell antigens in 259 classical Hodgkin's lymphoma cases using the tissue microarray technique. Expression of the T-cell antigens CD2, CD3, CD4, CD5, CD7 and CD8 was assessed by immunohistochemistry. Hodgkin's and Reed–Sternberg cells of T-cell marker-positive… 

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This case highlights pitfalls in the accurate diagnosis of PTCL as the expression of CD20 might lead one to suspect a B-cell neoplasm, whereas the expressionof CD30 and CD15 point toward diagnosis of classical Hodgkin’s lymphoma (cHL).

Nodal Involvement by Cutaneous CD30-positive T-cell Lymphoma Mimicking Classical Hodgkin Lymphoma

It is shown that cHL is less often associated with MF and primary cutaneous CD30-T-LPD than previously thought and that the coexpression of CD30 and CD15 in these TCLs may lead to a mistaken diagnosis of cHL.

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Expression of B-Cell Markers in Classical Hodgkin Lymphoma: A Tissue Microarray Analysis of 330 Cases

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9 well-characterized cases of B-cell non-Hodgkin lymphoma that showed aberrant expression of T-cell-associated antigens by 2-color flow cytometry are described and may prove invaluable to study aberrant activation of silent or repressed T- cell differentiation genes.

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Results show that PCR represents a specific and sensitive technique for the detection of IgH gene rearrangements in cases of Hodgkin's disease and suggest a lymphoid B-cell derivation of HRS cells in a high proportion of the cases.

The expression of the CD3 antigen in Hodgkin's disease

It appears that some Hodgkin and Reed‐Sternberg cells can express the major T‐cell antigen CD3, consistent with the hypothesis that at least some cases of Hodgkin's disease arise from activated T‐cells.

Expression of lymphoid‐associated antigens on Hodgkin's and Reed‐Sternberg cells of Hodgkin's disease. An immunocytochemical study on lymph node cytospins using monoclonal antibodies

A lymphoid (either T or B) rather than histiocytic origin for the Hodgkin's and Reed‐Sternberg cells in a number of Hodgkin’s disease cases is suggested.

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In two cases of cHD with H/RS cells expressing cytotoxic T cell molecules, the tumor cells are derived from mature B cells that aberrantly express T cell markers, demonstrating that cHD can also occur as a T cell lymphoma.

Molecular biology of Hodgkin's lymphoma.

Granzyme B expression in Reed-Sternberg cells of Hodgkin's disease.

It is concluded that in a restricted number of cases of Hodgkin's disease, the H-RS cells express granzyme B, and therefore might be considered the neoplastic equivalent of either activated CTLs or NK cells.

Immunoglobulin and T-cell receptor gene rearrangements in Hodgkin's disease.

The data do not confirm recent reports of a frequent occurrence of immunoglobulin or T-cell receptor gene rearrangements in Hodgkin's disease and suggest no possible relation between Reed-Sternberg cells and B- orT-lymphocytes, respectively.