Rare event selection of fetal nucleated erythrocytes in maternal blood by flow cytometry.

@article{Lewis1996RareES,
  title={Rare event selection of fetal nucleated erythrocytes in maternal blood by flow cytometry.},
  author={Dorothy E. Lewis and Wendy D. Schober and S. J. Murrell and Dianne D. Nguyen and James M Scott and J Boinoff and Joe Leigh Simpson and Farideh Z. Bischoff and Sherman Elias},
  journal={Cytometry},
  year={1996},
  volume={23 3},
  pages={218-27}
}
A noninvasive method of prenatal genetic diagnosis requires fetal cell selection from the maternal circulation that allows efficient recovery for analysis by fluorescence in situ hybridization (FISH). We have solved several problems that negatively affect the isolation and FISH analysis of fetal nucleated red blood cells (nRBCs) in the maternal circulation. The use of glycophorin A (Gly A) antibodies (Abs) for selection is problematic because all five monoclonal antibodies (mAbs) tested caused… CONTINUE READING

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