Rare cancer-specific mutations in PIK3CA show gain of function.

  title={Rare cancer-specific mutations in PIK3CA show gain of function.},
  author={Marco Gymnopoulos and Marc-Andr{\'e} Elsliger and Peter K. Vogt},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={104 13},
Fifteen rare cancer-derived mutants of PIK3CA, the gene coding for the catalytic subunit p110alpha of phosphatidylinositol 3-kinase (PI3K), were examined for their biological and biochemical properties. Fourteen of these mutants show a gain of function: they induce rapamycin-sensitive oncogenic transformation of chicken embryo fibroblasts, constitutively activate Akt and TOR-mediated signaling, and show enhanced lipid kinase activity. Mapping of these mutants on a partial structural model of… CONTINUE READING
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