Rare adverse reactions to non-steroidal anti-inflammatory drugs

@article{Wm1985RareAR,
  title={Rare adverse reactions to non-steroidal anti-inflammatory drugs},
  author={O'brien Wm and Bagby Gf},
  journal={The Journal of Rheumatology},
  year={1985},
  volume={12},
  pages={73-98}
}
This chapter attempts to survey the rare adverse reactions caused by non-steroidal anti-inflammatory drugs (NSAIDs). I shall summarize all the reported reactions to NSAIDs (a detailed review with 491 references is published elsewherel), and suggest any unusual reactions to individual drugs by comparing each drug with the accumulated experience with other NSAIDs over the past 20 years. After the withdrawals of both benoxaprofen (Oraflex, Opren) and zomepirac (Zomax), and the recent disquieting… 
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References

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Section 4 Adverse reactions to non-steroidal antirheumatic drugs
TLDR
The profiles show that both phenylbutazone and oxyphen butazone are predominantly associated with blood dyscrasias while indomethacin is predominantlyassociated with gastro-intestinal haemorrhage and minor reactions affecting the central nervous system.
An expanded profile of cutaneous reactions to nonsteroidal anti-inflammatory drugs. Reports to a specialty-based system for spontaneous reporting of adverse reactions to drugs.
TLDR
Reactions to piroxicam were most frequently reported; the majority of reactions to this drug were vesiculobullous and occurred most often in sun-exposed areas.
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TLDR
Evaluation of adverse reactions reported with diclofenac suggest a profile in which gastrointestinal side-effects predominate, however, the risk of serious side- effects of this nature is slight, and the impression of good tolerability which emerges from this review is confirmed by the findings of comparative clinical trials.
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TLDR
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TLDR
The following case represents a severe hypersensitivity reaction to sulindac, a nonsteroidal anti-inflammatory drug used in the treatment of rheumatoid arthritis, which is known to cause life-threatening hypersensitivity in some patients.
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TLDR
As indomethacin became available for use in general practice in March 1965 the authors are recording the experience of a group of 137 patients treated with 25-mg.
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TLDR
Two patients with multisystem involvement presumed to be secondary to NSAIDs are described, one with hepatocellular disease and the other with a cholestatic picture, both of which had renal failure consistent with acute tubular necrosis.
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