Rare adverse reactions to non-steroidal anti-inflammatory drugs

  title={Rare adverse reactions to non-steroidal anti-inflammatory drugs},
  author={O'brien Wm and Bagby Gf},
  journal={The Journal of Rheumatology},
This chapter attempts to survey the rare adverse reactions caused by non-steroidal anti-inflammatory drugs (NSAIDs). I shall summarize all the reported reactions to NSAIDs (a detailed review with 491 references is published elsewherel), and suggest any unusual reactions to individual drugs by comparing each drug with the accumulated experience with other NSAIDs over the past 20 years. After the withdrawals of both benoxaprofen (Oraflex, Opren) and zomepirac (Zomax), and the recent disquieting… 
Side-effects of non-steroidal anti-inflammatory drugs.
  • D. Henry
  • Medicine
    Bailliere's clinical rheumatology
  • 1988
CNS Adverse Effects of Nonsteroidal Anti-Inflammatory Drugs
SummaryIt is difficult to obtain valid estimations of the true incidence of CNS effects associated with nonsteroidal anti-inflammatory drugs (NSAIDs) from spontaneously reported adverse reactions.
Adverse Drug Interactions with Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
Adverse drug interactions involving NSAIDs may be limited by rational prescribing and by careful monitoring, particularly for high-risk patients, drugs and therapy periods.
Prediction of the clinical efficacy of and intolerance to antirheumatic drug therapy
The encouraging results seen initially following the use of 1 g of intravenous methylprednisolone have waned somewhat since the demonstration of equivalent short-term clinical effects using 1 g oral prednisol one and the fact that clinical and immunologic response is transient is transient.
Idiosyncratic liver toxicity of nonsteroidal antiinflammatory drugs: molecular mechanisms and pathology.
This review explores the clinical hepatic pathology associated with the use of nonsteroidal antiinflammatory drugs (NSAIDs), possible cellular and molecular mechanisms of injury, and future
Hepatorenal Effects of Ibuprofen Compared with other NSAIDs and Paracetamol
Overall, the evidence for serious liver reactions from ibuprofen and other NSAIDs suggests that these reactions are infrequent.
Short-term effects of antirheumatic drugs.
The Problems and Pitfalls of NSAID Therapy in the Elderly (Part I)
Although most NSAIDs have been reported to cause hepatotoxicity, serious abnormalities of liver function are rare and are largely unpredictable, and other adverse effects due to NSAID have also been described, some of which may be more common in the elderly.
Toxicity of nonsteroidal anti-inflammatory drugs in the large intestine
  • Neil Davies
  • Medicine
    Diseases of the colon and rectum
  • 1995
It is illustrated that NSAID-induced large bowel toxicity can cause significant morbidity in some patients, ranging from profuse diarrhea, chronic blood loss, and iron deficiency anemia to fatality.


Section 4 Adverse reactions to non-steroidal antirheumatic drugs
The profiles show that both phenylbutazone and oxyphen butazone are predominantly associated with blood dyscrasias while indomethacin is predominantlyassociated with gastro-intestinal haemorrhage and minor reactions affecting the central nervous system.
An expanded profile of cutaneous reactions to nonsteroidal anti-inflammatory drugs. Reports to a specialty-based system for spontaneous reporting of adverse reactions to drugs.
Reactions to piroxicam were most frequently reported; the majority of reactions to this drug were vesiculobullous and occurred most often in sun-exposed areas.
A review of spontaneously reported adverse drug reactions with diclofenac sodium (Voltarol).
Evaluation of adverse reactions reported with diclofenac suggest a profile in which gastrointestinal side-effects predominate, however, the risk of serious side- effects of this nature is slight, and the impression of good tolerability which emerges from this review is confirmed by the findings of comparative clinical trials.
Toxicity of indomethacin. Report of a case of acute pancreatitis.
This case gives evidence that indomethacin does have a direct and toxic effect on the pancreas, and is likely to be important in the cause of pancreatitis.
Life-threatening hypersensitivity to sulindac.
The following case represents a severe hypersensitivity reaction to sulindac, a nonsteroidal anti-inflammatory drug used in the treatment of rheumatoid arthritis, which is known to cause life-threatening hypersensitivity in some patients.
Further experience with indomethacin in the treatment of rheumatic disorders.
As indomethacin became available for use in general practice in March 1965 the authors are recording the experience of a group of 137 patients treated with 25-mg.
Acute multisystem toxicity associated with the use of nonsteroidal anti-inflammatory drugs.
Two patients with multisystem involvement presumed to be secondary to NSAIDs are described, one with hepatocellular disease and the other with a cholestatic picture, both of which had renal failure consistent with acute tubular necrosis.