• DOI:10.1039/c4ob00745j
Corpus ID: 20612722

Rare Streptomyces sp. polyketides as modulators of K-Ras localisation.

@article{Salim2014RareSS,
  title={Rare Streptomyces sp. polyketides as modulators of K-Ras localisation.},
  author={A. Salim and X. Xiao and Kwang-Jin Cho and Andrew M. Piggott and E. Lacey and J. Hancock and R. Capon},
  journal={Organic & biomolecular chemistry},
  year={2014},
  volume={12 27},
  pages={
          4872-8
        }
}

A. Salim, X. Xiao, +4 authors R. Capon

Published 2014

Chemistry, Medicine

Organic & biomolecular chemistry

Chemical investigations of a soil-derived Streptomyces sp. led to the isolation of five new polyketides, (+)-oxanthromicin, (±)-hemi-oxanthromicins A/B, (±)-spiro-oxanthromicin A and oxanthroquinone, and the known alkaloid staurosporine, and the detection of four new metastable analogues, (±)-spiro-oxanthromicins B1/B2/C1/C2. Among the compounds tested, SAR investigations established that the synthetic oxanthroquinone ethyl ester and 3-O-methyl-oxanthroquinone ethyl ester were optimal at… CONTINUE READING

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