Rare Streptomyces sp. polyketides as modulators of K-Ras localisation.

  title={Rare Streptomyces sp. polyketides as modulators of K-Ras localisation.},
  author={A. Salim and X. Xiao and Kwang-Jin Cho and Andrew M. Piggott and E. Lacey and J. Hancock and R. Capon},
  journal={Organic & biomolecular chemistry},
  volume={12 27},
  • A. Salim, X. Xiao, +4 authors R. Capon
  • Published 2014
  • Chemistry, Medicine
  • Organic & biomolecular chemistry
  • Chemical investigations of a soil-derived Streptomyces sp. led to the isolation of five new polyketides, (+)-oxanthromicin, (±)-hemi-oxanthromicins A/B, (±)-spiro-oxanthromicin A and oxanthroquinone, and the known alkaloid staurosporine, and the detection of four new metastable analogues, (±)-spiro-oxanthromicins B1/B2/C1/C2. Among the compounds tested, SAR investigations established that the synthetic oxanthroquinone ethyl ester and 3-O-methyl-oxanthroquinone ethyl ester were optimal at… CONTINUE READING
    14 Citations
    Oligomycins as inhibitors of K-Ras plasma membrane localisation.
    • 9
    • PDF
    Rare Streptomyces N-formyl amino-salicylamides inhibit oncogenic K-Ras.
    • 14
    An oxanthroquinone derivative that disrupts RAS plasma membrane localization inhibits cancer cell growth
    • 11
    • PDF
    Acylpeptide hydrolase is a novel regulator of KRAS plasma membrane localization and function
    • 7
    • PDF
    Recent Advances in Developing K-Ras Plasma Membrane Localization Inhibitors.
    • 2
    Depletion of phosphatidylinositol 4-phosphate at the Golgi translocates K-Ras to mitochondria
    • 2
    • PDF


    Structure-activity relationships of semisynthetic mumbaistatin analogs.
    • 14
    Staurosporines Disrupt Phosphatidylserine Trafficking and Mislocalize Ras Proteins*
    • 73
    • PDF
    Inhibition of Ras for cancer treatment: the search continues.
    • 325
    Ras proteins: different signals from different locations
    • J. Hancock
    • Biology, Medicine
    • Nature Reviews Molecular Cell Biology
    • 2003
    • 766
    • PDF