Rare ADH variant constellations are specific for alcohol dependence.

@article{Zuo2013RareAV,
  title={Rare ADH variant constellations are specific for alcohol dependence.},
  author={Lingjun Zuo and Heping Zhang and Robert Malison and Chiang-shan Ray Li and Xiang-yang Zhang and Fei Wang and Lingeng Lu and Lin Lu and Xiaoping Wang and John H. Krystal and Fengyu Zhang and Hong-Wen Deng and Xingguang Luo},
  journal={Alcohol and alcoholism},
  year={2013},
  volume={48 1},
  pages={9-14}
}
AIMS Some of the well-known functional alcohol dehydrogenase (ADH) gene variants (e.g. ADH1B*2, ADH1B*3 and ADH1C*2) that significantly affect the risk of alcohol dependence are rare variants in most populations. In the present study, we comprehensively examined the associations between rare ADH variants [minor allele frequency (MAF) <0.05] and alcohol dependence, with several other neuropsychiatric and neurological disorders as reference. METHODS A total of 49,358 subjects in 22 independent… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 30 references

Alcohol dehydrogenase alleles in Parkinson's disease.

Movement disorders : official journal of the Movement Disorder Society • 2000
View 10 Excerpts
Highly Influenced

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