Rapid warfarin reversal in anticoagulated patients with traumatic intracranial hemorrhage reduces hemorrhage progression and mortality.

@article{Ivascu2005RapidWR,
  title={Rapid warfarin reversal in anticoagulated patients with traumatic intracranial hemorrhage reduces hemorrhage progression and mortality.},
  author={Felicia A Ivascu and Greg A Howells and Fredrick S Junn and Holly A Bair and Phillip J Bendick and Randy J Janczyk},
  journal={The Journal of trauma},
  year={2005},
  volume={59 5},
  pages={1131-7; discussion 1137-9}
}
BACKGROUND A prospective cohort study at our institution demonstrated a 48% mortality rate in warfarin anticoagulated trauma patients sustaining intracranial hemorrhage (ICH) compared with a 10% mortality rate in nonanticoagulated patients. Forty percent of patients demonstrated progression of their ICH, despite anticoagulation reversal, with a resultant 65% mortality rate. Seventy-one percent of these patients initially presented with a Glasgow Coma Scale (GCS) score > or = 14 and a 'minor… CONTINUE READING
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