Rapid viral expansion and short drug half-life explain the incomplete effectiveness of current herpes simplex virus 2-directed antiviral agents.

@article{Schiffer2013RapidVE,
  title={Rapid viral expansion and short drug half-life explain the incomplete effectiveness of current herpes simplex virus 2-directed antiviral agents.},
  author={Joshua T. Schiffer and David A. Swan and Lawrence Corey and Anna Wald},
  journal={Antimicrobial agents and chemotherapy},
  year={2013},
  volume={57 12},
  pages={5820-9}
}
The nucleoside analogues acyclovir (ACV) and famciclovir (FCV) reduce the frequency and severity of herpes simplex virus 2 (HSV-2) genital shedding, yet despite their high potency in vitro and a lack of induced drug resistance, frequent episodes of breakthrough mucosal shedding occur. We tested a published stochastic, spatial mathematical model of HSV-2 replication and spread, in concert with pharmacokinetic and pharmacodynamic equations, against virologic data from clinical trials of twice… CONTINUE READING

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