Rapid upregulation of alpha7 nicotinic acetylcholine receptors by tyrosine dephosphorylation.

@article{Cho2005RapidUO,
  title={Rapid upregulation of alpha7 nicotinic acetylcholine receptors by tyrosine dephosphorylation.},
  author={Chang-Hoon Cho and Weifeng Song and Katherine Leitzell and Esther H Teo and Annal D Meleth and Michael W. Quick and Robin A. J. Lester},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2005},
  volume={25 14},
  pages={3712-23}
}
Alpha7 nicotinic acetylcholine receptors (nAChRs) modulate network activity in the CNS. Thus, functional regulation of alpha7 nAChRs could influence the flow of information through various brain nuclei. It is hypothesized here that these receptors are amenable to modulation by tyrosine phosphorylation. In both Xenopus oocytes and rat hippocampal interneurons, brief exposure to a broad-spectrum protein tyrosine kinase inhibitor, genistein, specifically and reversibly potentiated alpha7 nAChR… CONTINUE READING

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Alpha7 neuronal nicotinic acetylcholine receptors are negatively regulated by tyrosine phosphorylation and Src-family kinases.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2005
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