Rapid turnover rate of phosphoinositides at the front of migrating MDCK cells.

Abstract

Phosphoinositides (PtdInss) play key roles in cell polarization and motility. With a series of biosensors based on Förster resonance energy transfer, we examined the distribution and metabolism of PtdInss and diacylglycerol (DAG) in stochastically migrating Madin-Darby canine kidney (MDCK) cells. The concentrations of phosphatidylinositol (4,5)-bisphosphate… (More)
DOI: 10.1091/mbc.E08-03-0315

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