Rapid turnover of the mTOR complex 1 (mTORC1) repressor REDD1 and activation of mTORC1 signaling following inhibition of protein synthesis.

@article{Kimball2008RapidTO,
  title={Rapid turnover of the mTOR complex 1 (mTORC1) repressor REDD1 and activation of mTORC1 signaling following inhibition of protein synthesis.},
  author={Scot R. Kimball and Annamuradov Do and Lydia Kutzler and Douglas R Cavener and Leonard S. Jefferson},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 6},
  pages={
          3465-75
        }
}
mTORC1 is a complex of proteins that includes the mammalian target of rapamycin (mTOR) and several regulatory proteins. It is activated by a variety of hormones (e.g. insulin) and nutrients (e.g. amino acids) that act to stimulate cell growth and proliferation and repressed by hormones (e.g. glucocorticoids) that act to reduce cell growth. Curiously, mTORC1 signaling is reported to be rapidly (e.g. within 1-2 h) activated by inhibitors of protein synthesis that act on either mRNA translation… CONTINUE READING
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