Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection

@article{Ho1995RapidTO,
  title={Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection},
  author={David D. Ho and Avidan U. Neumann and Alan S. Perelson and Wen Chen and John M. Leonard and Martin Markowitz},
  journal={Nature},
  year={1995},
  volume={373},
  pages={123-126}
}
Treatment of infected patients with ABT-538, an inhibitor of the protease of human immuno-deficiency virus type 1 (HIV-1), causes plasma HIV-1 levels to decrease exponentially (mean half-life, 2.1 ±0.4 days) and CD4 lymphocyte counts to rise substantially. Minimum estimates of HIV-1 production and clearance and of CD4 lymphocyte turnover indicate that replication of HIV-1 in vivo is continuous and highly productive, driving the rapid turnover of CD4 lymphocytes. 
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