Rapid transport of muco-inert nanoparticles in cystic fibrosis sputum treated with N-acetyl cysteine.

@article{Suk2011RapidTO,
  title={Rapid transport of muco-inert nanoparticles in cystic fibrosis sputum treated with N-acetyl cysteine.},
  author={Jung Soo Suk and Samuel K Lai and Nicholas J. Boylan and Michelle R Dawson and Michael P Boyle and Justin Hanes},
  journal={Nanomedicine},
  year={2011},
  volume={6 2},
  pages={365-75}
}
AIMS Sputum poses a critical diffusional barrier that strongly limits the efficacy of drug and gene carriers in the airways of individuals with cystic fibrosis (CF). Previous attempts to enhance particle penetration of CF sputum have focused on either reducing its barrier properties via mucolytics, or decreasing particle adhesion to sputum constituents by coating the particle surface with non-mucoadhesive polymers, including polyethylene glycol (PEG). Neither approach has enabled particles to… CONTINUE READING

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