Rapid translocation of Zn(2+) from presynaptic terminals into postsynaptic hippocampal neurons after physiological stimulation.

@article{Li2001RapidTO,
  title={Rapid translocation of Zn(2+) from presynaptic terminals into postsynaptic hippocampal neurons after physiological stimulation.},
  author={Ying-Shun Li and Christopher J Hough and Sang Won Suh and John M. Sarvey and Christopher J. Frederickson},
  journal={Journal of neurophysiology},
  year={2001},
  volume={86 5},
  pages={2597-604}
}
Zn(2+) is found in glutamatergic nerve terminals throughout the mammalian forebrain and has diverse extracellular and intracellular actions. The anatomical location and possible synaptic signaling role for this cation have led to the hypothesis that Zn(2+) is released from presynaptic boutons, traverses the synaptic cleft, and enters postsynaptic neurons. However, these events have not been directly observed or characterized. Here we show, using microfluorescence imaging in rat hippocampal… CONTINUE READING
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