Rapid tolerance and cross-tolerance as predictors of chronic tolerance and cross-tolerance

@article{Khanna1992RapidTA,
  title={Rapid tolerance and cross-tolerance as predictors of chronic tolerance and cross-tolerance},
  author={Jatinder M. Khanna and Harold. Kalant and J. Weiner and G. Shah},
  journal={Pharmacology Biochemistry and Behavior},
  year={1992},
  volume={41},
  pages={355-360}
}
Hypothermia and motor impairment (tilt-plane) tests were used to assess the phenomenon of rapid tolerance to ethanol and cross-tolerance to various alcohols, benzodiazepines, and barbiturates that differ in lipid:water partition coefficients. The hypothermic and motor impairment responses to ethanol were significantly reduced on day 2 in rats receiving ethanol (2 doses of 2 g/kg each for the hypothermia test and 2.3 and 1.7 g/kg for the tilt-plane test) 24 and 22 h earlier compared to the… Expand
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References

SHOWING 1-10 OF 13 REFERENCES
Rapid tolerance as an index of chronic tolerance
TLDR
Determination of ethanol and pentobarbital blood levels suggested that pharmacokinetic alterations did not contribute significantly to the observed rapid tolerance and cross-tolerance, and the results suggest that rapidolerance andCross-toler can be used as predictors of chronic tolerance and Cross-Tolerance. Expand
Tolerance to ethanol and cross-tolerance to pentobarbital and barbital
TLDR
The difference in the extent of cross-tolerance between ethanol and the two barbiturates is consistent with the hypothesis that there is a degree of specificity in the sites of action of ethanol and other sedative-hypnotic drugs. Expand
Effect of chronic pentobarbital treatment on the development of cross-tolerance to ethanol and barbital
TLDR
Determination of ethanol blood levels as well as a complete time course of absorption, distribution and elimination of ethanol suggested that pharmacokinetic alterations may play a role in the development of cross-tolerance to ethanol in pentobarbital-treated subjects. Expand
Cross-tolerance between ethanol and chlordiazepoxide.
TLDR
Mice chronically treated with ethanol showed a similar degree of cross-tolerance to CDP compared to those exposed to an acute dose of ethanol, while C57BL/6J mice did not develop tolerance to the drug. Expand
Rapid development of tolerance to the hypothermic effect of ethanol in mice.
TLDR
It appears, therefore, that the reduced change in body temperature is indicative of tolerance, and since tolerance was already present 10 min after the second ethanol injection, a functional rather than a metabolic tolerance is likely. Expand
Learning factor in rapid tolerance to ethanol-induced motor impairment
TLDR
Not only the opportunity to practice, but also its extent and possibly its quality are important determinants in the rapid development of intersessional tolerance in Wistar rats. Expand
Barbiturate Anesthesia and Alcohol Tolerance in A Rat Model
TLDR
It is suggested that because shorter-acting barbiturates show negligible cross-tolerance with alcohol, higher doses of these agents may not be required for satisfactory anesthesia in chronically alcoholic humans. Expand
Effects of Chronic Alcohol Intake on Anesthetic Responses to Diazepam and Thiopental in Rats
TLDR
Chronic alcohol intake sufficient to produce tolerance to anesthetic doses of alcohol in rats also produced cross-tolerance to diazepam but not to thiopental in equianesthetic doses, suggesting that blanket recommendations for adjusting intravenous anesthetic dosages in alcoholic humans may be inadequate as guides to anesthesia management. Expand
Chronic treatment with ethanol or chlordiazepoxide alters the metabolism of chlordiazepoxide
TLDR
Chronic CDP treatment affected the absorption and distribution of ethanol, providing a metabolic basis for the manifestations of CDP tolerance and ethanol cross-tolerance that have been reported in CDP-dependent mice. Expand
Alcohols stimulate γ-aminobutyric acid receptor-mediated chloride uptake in brain vesicles: correlation with intoxication potency
TLDR
The data suggest that the anxiolytic, sedative/hypnotic and intoxicating properties of ethanol may, in part, be mediated via an action at central GABA receptors. Expand
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