Rapid target gene validation in complex cancer mouse models using re-derived embryonic stem cells

@inproceedings{Huijbers2014RapidTG,
  title={Rapid target gene validation in complex cancer mouse models using re-derived embryonic stem cells},
  author={Ivo J. Huijbers and Rahmen Bin Ali and Colin C. Pritchard and Miranda Cozijnsen and M Kwon and Natalie Proost and J. Song and Hilda I. de Vries and Jitendra Badhai and Kate Sutherland and Paul J. A. Krimpenfort and Ewa M Michalak and Jos Jonkers and Anton Berns},
  booktitle={EMBO molecular medicine},
  year={2014}
}
Human cancers modeled in Genetically Engineered Mouse Models (GEMMs) can provide important mechanistic insights into the molecular basis of tumor development and enable testing of new intervention strategies. The inherent complexity of these models, with often multiple modified tumor suppressor genes and oncogenes, has hampered their use as preclinical models for validating cancer genes and drug targets. In our newly developed approach for the fast generation of tumor cohorts we have overcome… CONTINUE READING