Rapid stimulation of hepatic oxygen consumption by 3,5-di-iodo-L-thyronine.

@article{Horst1989RapidSO,
  title={Rapid stimulation of hepatic oxygen consumption by 3,5-di-iodo-L-thyronine.},
  author={Christian Horst and Hartmut Dr. Rokos and Hans Joachim Seitz},
  journal={The Biochemical journal},
  year={1989},
  volume={261 3},
  pages={
          945-50
        }
}
Tri-iodothyronine (T3) and thyroxine (T4) as well as 3,5-di-iodothyronine (T2) stimulated O2 consumption by isolated perfused livers from hypothyroid rats at a concentration as low as 1 pM by about 30% within 90 min. Application of T2 resulted in a faster stimulation than with application of T3 or T4. Inhibition of iodothyronine monodeiodinase by propylthiouracil, thereby blocking the degradation of T4 to T3 and of T3 to T2, demonstrated that only T2 is the active hormone for the rapid… CONTINUE READING

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