Rapid spinogenesis of pyramidal neurons induced by activation of glucocorticoid receptors in adult male rat hippocampus.

@article{Komatsuzaki2005RapidSO,
  title={Rapid spinogenesis of pyramidal neurons induced by activation of glucocorticoid receptors in adult male rat hippocampus.},
  author={Yoshimasa Komatsuzaki and Gen Murakami and Tomokazu Tsurugizawa and Hideo Mukai and Nobuaki Tanabe and Kenji Mitsuhashi and Mitsuhiro Kawata and Tetsuya Kimoto and Yuuki Ooishi and S Kawato},
  journal={Biochemical and biophysical research communications},
  year={2005},
  volume={335 4},
  pages={
          1002-7
        }
}
Modulation of hippocampal synaptic plasticity by glucocorticoids has been attracting much attention, due to its importance in stress responses. Dendritic spines are essential for memory storage processes. Here, we investigated the effect of dexamethasone (DEX), a specific agonist of glucocorticoid receptor (GR), on density and morphology of dendritic spines in adult male rat hippocampus by imaging of Lucifer Yellow-injected spines in slices. The application of 100 nM DEX (stressful high… CONTINUE READING
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Acute effect of corticosterone on N - methyl - D - aspartate receptor - mediated Ca 2 + elevation in mouse hippocampal slices

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